In the two previous league meetings at the ground, Stoke have been thumped 5-0 and 4-0.
Pulis is hoping they will not be quite so generous again when he goes face to face in the dugout with Sir Alex Ferguson.
Stoke go into the match on the back of a 2-0 victory against Everton and Pulis said: "We will go to Old Trafford and give it our best shot.
"We have run them close at our place but not at Old Trafford. We have struggled there. Hopefully we can give a good account of ourselves."