The Europa League game is the Potters’ third important cup game in a week and they are far from being the favourites after losing the first leg 1-0 at the Britannia Stadium last week.
After the Valencia trip, Stoke return to England for an important game against Swansea and that is a game that everyone thought Pulis would put in a stronger side than for the game in Spain, but the Stoke boss says that is not the case.
But he does know that his side will have to be at 110 per cent if they are to overcome a 1-0 deficit.
"We'll give it our best," he said.
"They are a top team and I was very, very impressed on Thursday night. They have a all the tools in their armour to be a top side and they are a Champions League team, really. They're not a Europa League side.
"There was a step up between what we have played in that competition, but it was lovely to be part of it. These are fantastic times at the football club, playing Valencia and the like.
"We're in the FA Cup quarter-finals for the third year running and it has been a great rollercoaster for us as a football club."